Autocatalytic base editing for RNA-responsive translational control

Genetic circuits that control transgene expression in response to pre-defined transcriptional Phased Array TV Antenna cues would enable the development of smart therapeutics.Here the authors engineer programmable RNA sensors, DART VADARs, in which ADARs Lid Switch autocatalytically convert target hybridization into a translational output, thus amplifying editing by endogenous ADAR via positive feedback and conferring high dynamic range and a small genetic footprint.